Target Protein Ligand-Linker Conjugates
Target Protein Ligand-Linker Conjugate incorporates a ligand for the target protein and a linker. When binding to an E3 ligase ligand, the conjugate will be a PROTAC with ability to induce ubiquitylation and subsequent degradation the protein of interest.
Target proteins are usually proteins whose overexpression or accumulation may play important roles in the progress of diseases. Numbers of PROTACs have been developed to degrade kinases, transcription factors, epigenetic tools and E3 ligase themselves.
The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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Target Protein Ligand-Linker Conjugates Related Products (138)
Related Products (138)
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PROTAC SMARCA2 degrader-1
0 ImagesCat. No.: HY-153424CAS No.: 2892523-73-6
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DHPT-PEG2-C2-NH2
0 ImagesCat. No.: HY-184481CAS No.: 2133002-45-4DHPT-PEG2-C2-NH2 (Compound 15) is a Target Protein Ligand-Linker Conjugate that contains an Htt ligand (HY-W040269) and a PROTAC linker (HY-W007545), and can recruit E3 ligases. JQ-1-Azidopropylamine is applicable for the synthesis of PROTAC HTT Degrader-1 (HY-184480).
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FLT3 Ligand-Linker Conjugate 1
0 ImagesCat. No.: HY-170769CAS No.: 2769753-49-1FLT3 Ligand-Linker Conjugate 1 (compound 7) contains the FLT3 ligand and a PROTAC linker, which can recruit the E3 ligase VHL. FLT3 Ligand-Linker Conjugate 1 can be used to synthesize the PROTAC RSS0680 (HY-148062). PROTAC RSS0680 is a bifunctional compound that targets protein degradation of kinases.
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Adavosertib-C3-NH-Boc
0 ImagesCat. No.: HY-176363CAS No.: 2113725-19-0Adavosertib-C3-NH-Boc is a Target Protein Ligand-Linker Conjugate that incorporates a ligand for Wee1 (HY-10993) and a PROTAC linker (HY-W011561), which recruits E3 ligases. Adavosertib-C3-NH-Boc can be used for synthesis of PROTAC Pomalidomide-C3-adavosertib (HY-133618).
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JQ-1 (carboxylic acid)-NH-Pip
0 ImagesCat. No.: HY-175626CAS No.: 3058844-99-5
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cGAS-IN-5-CH2-amido-C9-NH2
0 ImagesCat. No.: HY-187080CAS No.: 3060522-48-4
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SMARCA2 Ligand-Linker Conjugate-4
0 ImagesCat. No.: HY-176872CAS No.: 3033001-29-2
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ALK5 ligand-1-amine-C2-piperazine-C4-OH
0 ImagesCat. No.: HY-183442ALK5 ligand-1-amine-C2-piperazine-C4-OH is a conjugate of a ligand targeting ALK5 and a PROTAC linker. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be used to synthesize the PROTAC degrader (a31). ALK5 PROTACs induce UPS-dependent and selective degradation of ALK5 over ALK4. ALK5 ligand-1-amine-C2-piperazine-C4-OH can be applied to research on pulmonary fibrosis.
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N-(8-Carboxyoctanoyl)-deacetyl BMS-202
0 ImagesCat. No.: HY-182980N-(8-Carboxyoctanoyl)-deacetyl BMS-202 is a target protein ligand-linker conjugate. N-(8-Carboxyoctanoyl)-deacetyl BMS-202 contains the target protein PD-1/PD-L1 ligand and a PROTAC linker. N-(8-Carboxyoctanoyl)-deacetyl BMS-202 can be used for the synthesis of PROTAC PD-L1 Degrader-3 (HY-182959).
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N-Deshydroxyethyl Dasatinib-C3-NH2
0 ImagesCat. No.: HY-175193CAS No.: 1430089-58-9Synonyms: N-Deshydroxyethyl BMS-354825-C3-NH2N-Deshydroxyethyl Dasatinib-C3-NH2 is an Target Protein Ligand-Linker Conjugate that incorporates a ligand for LCK (HY-107447) and a PROTAC linker (HY-76667), which recruits E3 ligases. N-Deshydroxyethyl Dasatinib-C3-NH2 can be used for synthesis of PROTAC SJ11646 (HY-175281).
